Purpose: Breast cancer is the most common cause of cancer, and is the second most common cause of cancer-related deaths in women in the United States. Furthermore, the gastrointestinal tract is an uncommonly reported site for metastatic disease of the breast, with the majority of metastasis involving the stomach. Although described in only a handful of cases in women, to our knowledge and extensive literature search, this is the first report of a rectal metastasis from breast cancer in a male patient. We present a case of a 63-year-old male with past medical history of HER 2 positive intraductal breast cancer, diagnosed in 2000 and treated with a modified radical mastectomy, lymph node dissection, and herceptin and aromatase inhibitor therapy. In 2007, he was found to have bony metastasis, after which he resumed chemotherapy until 2010. Patient now presented to our hospital with progressive generalized weakness, nausea, vomiting, and significant diarrhea over the past two months. He reported having approximately 10 bowel movements a day, which resulted in a 25-pound weight loss. On presentation, he also complained of urgency associated with fecal incontinence and decreased appetite. Patient's vital signs were within normal limits. On physical exam, he was alert, with evidence of dry mucous membranes, and otherwise an unremarkable cardiopulmonary and abdominal exam. His laboratory blood work was significant for hemoglobin of 10.3 mg/dl, a normal basic metabolic panel, and negative stool studies for infection. A previous colonoscopy in 2006 was normal. Patient's upper endoscopy showed no signs of bleeding, infection or malignancy. His colonoscopy showed a circumferential villous-appearing mass at 12 cm from the entry site with a narrowed lumen, which was difficult to traverse. An ultra-thin endoscope was used to maneuver through the strictured mass, measuring 5 cm and located from 12 cm to 17 cm from the entry site. Multiple mucosal biopsies from this lesion showed normal colonic mucosa without any evidence of dysplasia or malignancy. A follow-up rectal endoscopic ultrasound showed a submucosal mass measuring 3.3 cm by 1.9 cm, breaching the muscularis propria. Fine needle biopsy showed highly atypical discohesive cells resembling patient's breast cancer histology and immunostaining positive for cytokeratin 7, 20, and GCDFP-15, consistent with patient's breast cancer. He is being evaluated by oncology and colorectal surgery with a plan for chemotherapy. Our case highlights a rare occurrence of metastatic breast cancer to the rectum in a male patient, which should be a part of the differential diagnosis for patients presenting with gastrointestinal complaints after a history of breast cancer, regardless of patient gender.